OUR VISION

Computational Metabolomics for “Natural Product” Drug Discovery

From aspirin, to penicillin, to rapamycin, the natural world has been, and continues to be, a prolific source of medically relevant chemical starting points for groundbreaking therapeutics. Unfortunately, typical approaches in this field are plagued by long-timelines and sample complexity. Since 2012, Sirenas has been the pioneer and global leader in harnessing computational metabolomics for the discovery of small molecule therapeutic leads from natural sources. Our approach, dubbed ATLANTIS™, unleashes cutting-edge computational algorithms on large, proprietary metabolomic and bioassay datasets to rapidly uncover key chemical and biological insights for the small molecules present in complex samples from extremely biodiverse environments. The end result: the ability to mine a vastly untapped chemical language for new chemical scaffolds effective across a broad array of high value targets and disease models.

THE TEAM

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Eduardo Esquenazi, PhD Founder, Chief Executive Officer
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Jake Beverage, PharmD Co-founder
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Phil Baran, PhD Co-founder
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Eduardo Esquenazi, PhD Founder, Chief Executive Officer
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Mary Haak – Frendscho, PhD Board Member
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Bob More Board Member
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Jake Beverage, PharmD Co-founder
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Phil Baran, PhD Co-founder
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Benjamin Cravatt, PhD Scientific Adviser
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Terry Rosen, PhD Scientific Adviser
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Pieter Dorrestein, PhD Scientific Adviser
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Christopher Walsh, PhD Scientific Adviser
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Jin-Quan Yu, PhD Scientific Adviser
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Bill Gerwick, PhD Scientific Adviser
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Eduardo Esquenazi, PhD Founder, Chief Executive Officer
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Jake Beverage, PharmD Co-founder
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Phil Baran, PhD Co-founder

PIPELINE

IN THE NEWS

What the world is buzzing about Sirenas

02.12.18

Sirenas Enters Into Multi-Target Collaboration With Bristol-Myers Squibb. View press release.

12.13.17

Sirenas receives research grant totaling $1.68 M to accelerate its drug discovery technology, ATLANTIS™. View press release.

08.15.17

Sirenas establishes world leading Scientific Advisory Board. View press release.

08.08.17

Sirenas appoints industry leaders to its Board. View press release.

06.15.17

CEO and Founder Eduardo Esquenazi shares “The Secret Language of Life” at TEDxUCSD. Watch the full TED talk.

12.23.16

HATCH by San Diego Magazine captures the story of Founder and CEO Eduardo Esquenazi and how it shaped Sirenas. Read full article.

12.08.16

Founder and CEO Eduardo Esquenazi speaks with the Smithsonian about his journey and the path forward for Sirenas LLC. Read full interview.

10.26.16

Learn more about how Sirenas is meeting the challenges of natural product discovery in a feature by Fast Company’s Fast Co.Exist!

10.18.16

Sirenas and Calibr form a drug discovery collaboration. View press release.

10.17.16

Sirenas is a panel finalist for South by Southwest 2017! Alongside Fabien Cousteau, Sirenas CEO Eduardo Esquenazi will address “Racing Climate Change to Cure Neglected Diseases” – Read full panel description.

10.03.16

CEO Eduardo Esquenazi speaks with Xconomy about Sirenas’ key innovation. Learn more.

09.29.16

Sirenas is awarded a grant to identify nature-inspired drug leads for neglected diseases. View press release.

09.29.16

The San Diego Business Journal features Sirenas in the wake of grant announcement.  Read more.

08.17.16

On this week’s BioTech Nation, looking for new drugs … in the ocean. Dr. Eduardo Esquenazi, Founder and CEO of Sirenas LLC, talks about bioprospecting.  Listen to full podcast.

CONTACT US

We’d Like to Hear From You

Sirenas
3550 General Atomics Court. Suite 02/211
San Diego, CA 92121
email: [email protected] / ph 858-909-5685

Drop Us a Line

Sirenas creates and connects large scale metabolomic data with cutting-edge technology and algorithms to efficiently yield breakthrough medical discoveries. We are actively looking for talented individuals to join our innovative team.

Email[email protected]