Metabolites, low-molecular weight organic molecules, are a constant product of living biological systems. Unlike genes, metabolites are temporally dynamic, changing as an organism or cell population lives, feeds, ages and develops disease.  The comprehensive analysis of metabolites in a system, or metabolomics, can provide a deep and incredibly insightful picture of a living system.  

Within the metabolome of living systems, microbiota play a significant role. Recent scientific studies reveal that well over 99% of life on our planet is microbial.  This microbial “dark matter” is enormous and found not only within us (the human microbiome) but all around us. With no teeth, scales, traditional nervous systems or immunity, these organisms rely exclusively on complex metabolites to communicate, mediate their environments and even control their hosts. This ancient, highly evolved, and diverse chemical language is a vastly untapped source of new disease insights and potential starting points for new medicines.

THE TEAM

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Jake Beverage, PharmD Chief Executive Officer, Co-founder
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Eduardo Esquenazi, PhD Founder, Chairman, Head of Innovation
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Phil Baran, PhD Co-founder
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Eduardo Esquenazi, PhD Founder, Chairman, Head of Innovation
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Mary Haak – Frendscho, PhD Board Member
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Bob More Board Member
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Jake Beverage, PharmD Chief Executive Officer, Co-founder
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Phil Baran, PhD Co-founder
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Benjamin Cravatt, PhD Scientific Adviser
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Terry Rosen, PhD Scientific Adviser
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Pieter Dorrestein, PhD Scientific Adviser
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Christopher Walsh, PhD Scientific Adviser
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Jin-Quan Yu, PhD Scientific Adviser
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Alan Ezekowitz, MBChB, DPhil Scientific Adviser
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Doron Shabat, PhD Scientific Adviser
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Bill Gerwick, PhD Scientific Adviser
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Jake Beverage, PharmD Chief Executive Officer, Co-founder
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Eduardo Esquenazi, PhD Founder, Chairman, Head of Innovation
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Phil Baran, PhD Co-founder

PARTNERSHIPS

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PIPELINE

IN THE NEWS

What the world is buzzing about Sirenas

02.12.18

Sirenas Enters Into Multi-Target Collaboration With Bristol-Myers Squibb. View press release.

12.13.17

Sirenas receives research grant totaling $1.68 M to accelerate its drug discovery technology, ATLANTIS™. View press release.

08.15.17

Sirenas establishes world leading Scientific Advisory Board. View press release.

08.08.17

Sirenas appoints industry leaders to its Board. View press release.

06.15.17

CEO and Founder Eduardo Esquenazi shares “The Secret Language of Life” at TEDxUCSD. Watch the full TED talk.

12.23.16

HATCH by San Diego Magazine captures the story of Founder and CEO Eduardo Esquenazi and how it shaped Sirenas. Read full article.

12.08.16

Founder and CEO Eduardo Esquenazi speaks with the Smithsonian about his journey and the path forward for Sirenas LLC. Read full interview.

10.26.16

Learn more about how Sirenas is meeting the challenges of natural product discovery in a feature by Fast Company’s Fast Co.Exist!

10.18.16

Sirenas and Calibr form a drug discovery collaboration. View press release.

10.17.16

Sirenas is a panel finalist for South by Southwest 2017! Alongside Fabien Cousteau, Sirenas CEO Eduardo Esquenazi will address “Racing Climate Change to Cure Neglected Diseases” – Read full panel description.

10.03.16

CEO Eduardo Esquenazi speaks with Xconomy about Sirenas’ key innovation. Learn more.

09.29.16

Sirenas is awarded a grant to identify nature-inspired drug leads for neglected diseases. View press release.

09.29.16

The San Diego Business Journal features Sirenas in the wake of grant announcement.  Read more.

08.17.16

On this week’s BioTech Nation, looking for new drugs … in the ocean. Dr. Eduardo Esquenazi, Founder and CEO of Sirenas LLC, talks about bioprospecting.  Listen to full podcast.

CONTACT US

We’d Like to Hear From You

Sirenas
3550 General Atomics Court. Suite 02/211
San Diego, CA 92121
email: info@sirenasmd.com / ph 858-909-5685

Drop Us a Line

Sirenas creates and connects large scale metabolomic data with cutting-edge technology and algorithms to efficiently yield breakthrough medical discoveries. We are actively looking for talented individuals to join our innovative team.

Emailcareers@sirenasmd.com